In this paper, we sketch a framework for interdisciplinary modeling of space systems, by proposing
a holistic view. We consider different system dimensions and their interaction. Specifically,we study the interactions between computation, physics, communication, uncertainty and autonomy.
The most comprehensive computational paradigm that supports a holistic perspective on autonomous space systems is given by cyber-physical systems. For these, the state of art consists of collaborating multi-engineering efforts that prompt for an adequate formal foundation.